oxygen.microgradient.chip.

Our device generates 1D and 2D gas microgradients with microscale precision and has the potential to test the effect of localized oxygen delivery on a wide range of tissues and cell samples. The developed microgradient profiles will be stable for over seven days, enabling experiments of physiologically relevant duration. Importantly, the microgradient profile is user-defined at the time of the experiment, adjustable during the course of an experiment and actively responsive to transient experimental conditions. Among the many applications for this device, we initially intend to use it to study hypoxia in tumor tissue. Other uses include the screening metabolism and product producton profiles across an entire oxygen spectrum and the exploration of aerotaxis and 'energy taxis' in cells.

J. H. Park, T. Bansal, M. Pinelis, M. M. Maharbiz, “Electrolytic patterning of dissolved oxygen microgradients during cell culture,” Lab on a Chip, 6, pg. 611-622, 2006.
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