SERS Science & Technology Fundamentals
Ming C. Wu, Eli Yablonovitch, Constance Chang-Hasnain, Jeffrey Bokor, Andrew R. Neureuther, Luke Lee1, Jim Schuck2, Stefano Cabrini3, Jeff Neaton4, Matteo Staffaroni, Tae Joon Seok, Arash Jamshidi and Amit Lakhani
Defense Advanced Research Projects Agency
Surface Enhanced Raman Scattering (SERS) is a powerful technique for detecting biological and chemical warfare agents as the Raman spectrum provide a unique fingerprint of molecules and unique label-free detection capability without typical fluorescent labeling steps. Though single molecule detection has been reported using SERS, a key difficulty has been the lack of control of the hot spots that give huge signals, such as those found in the inhomogeneous arrays of metal particles in aqueous solutions The goal of this project is to develop a systematic understanding of the enhancement factors in SERS. We propose to use nano-optical transformers to match the impedances of the molecules and the optical antenna, leading to predictable, engineerable, and reproducible large SERS enhancement.
1UC Berkeley Bioengineering
2LBNL Molecular Foundry
3LBNL Molecular Foundry
4LBNL Molecular Foundry